Vascular smooth muscle phenotypic diversity and function
نویسندگان
چکیده
منابع مشابه
Vascular smooth muscle phenotypic diversity and function.
The control of force production in vascular smooth muscle is critical to the normal regulation of blood flow and pressure, and altered regulation is common to diseases such as hypertension, heart failure, and ischemia. A great deal has been learned about imbalances in vasoconstrictor and vasodilator signals, e.g., angiotensin, endothelin, norepinephrine, and nitric oxide, that regulate vascular...
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G protein-coupled receptors regulate two major functions of vascular smooth muscle cells (SMCs) the vasomotor contractile response and the proliferative response. The contractile phenotype of SMCs has mainly been studied in situ within intact blood vessels, whereas the synthetic or proliferative SMC phenotypes can be studied in culture and represent a model of the SMC phenotype seen in vascular...
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The origins of vascular smooth muscle are far more diverse than previously thought. Lineage mapping studies show that the segmental organization of early vertebrate embryos leaves footprints on the adult vascular system in the form of a mosaic pattern of different smooth muscle types. Moreover, evolutionarily conserved tissue forming pathways produce vascular smooth muscle from a variety of una...
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C ardiovascular diseases, such as ischemic heart disease and stroke, represent the number one cause of death worldwide. 1 In most cases, atherosclerosis and hypertension constitute the underlying causes for cardiovascular disease because it leads to arterial occlusion and impaired cardiac function, respectively. Therapeutic compensation of atherosclerotic artery occlusion by bypass grafting, an...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2010
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00111.2010